Molecular approaches to personalizing management of ovarian cancer
نویسندگان
چکیده
منابع مشابه
Molecular approaches to personalizing management of ovarian cancer.
Cytoreductive surgery and empirical combination chemotherapy have improved 5-year survival for ovarian cancer patients, but have not increased the overall rate of cure. Poor outcomes relate, at least in part, to late diagnosis and to the persistence of dormant ovarian cancer cells that have resisted conventional drugs. Increased understanding of the molecular, cellular and clinical biology of o...
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P reliminary results from an ovarian cancer screening test that relies on person-alized findings from an annual CA125 blood test are keeping alive hope that someday an effective screening tool for the disease may be a reality. But researchers warn that the method is not perfect and that proof that it decreases the risk of dying from the rare but deadly cancer is still several years away. Resear...
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Ovarian cancer is the fifth largest cause of cancer-related death in females in the USA [1]. It is estimated that 15,000 women died from ovarian cancer in 2009. These dismal statistics result, in part, from the advanced stage at which ovarian cancer is diagnosed. The symptoms for ovarian cancer, which include abdominal or pelvic discomfort, urinary frequency, bloating or early satiety, are ofte...
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Screening trials for the early detection of ovarian cancer in the general population and in patients at a high risk for this disease have so far failed to show a reduction of ovarian cancer-specific mortality. Current screening modalities include pelvic examinations, transvaginal ultrasounds, and cancer antigen 125 (CA125) serum marker levels, which are associated with a high false-positive rat...
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Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring ...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2011
ISSN: 0923-7534
DOI: 10.1093/annonc/mdr516